PCL201H1 Lecture 9: Lecture 9 Drug Distribution
Document Summary
Volume of distribution (actual: anatomical volume accessible to the drug, e. g. Charged compound (ecf can"t diffuse across membrane) vs. uncharger nonpolar compound (can distribute to different areas, tbw: ecf vs tbw = 12l vs 42l. The hypothetical volume necessary to contain homogenous concentration in blood, plasma, or water: vd can be measure and calculated following iv injection of known compounds. Large vd not concentrated (low mw, hydropholic (lipid soluble), access to more through diffusion through membranes) Intermediate vd concentrated in a smaller area ecf (can"t readily cross membranes) Small vd quite concentrated drug is concentrated in plasma compartment. Vd provides information on where a drug will be found and where it won"t be found. Why is vd important: knowing the vd of a drug allows us to calculate the dose required to achieve a desired plasma concentration. In practice: works with respect to calculating drug concentrations, does not provide nformation on if the drug is effective.
