Physiology 1021 Study Guide - Midterm Guide: Christian Bohr, Juxtaglomerular Cell, Antiporter

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Gas exchange takes place in the alveoli at the blood-gas-barrier (separates blood in the pulmonary capillary from air in the alveoli: air is brought to the other side by pulmonary circulation. 2 major divisions of the lungs: conducting zone (anatomical deadspace): Alveoli: smallest functional unit of the lung, from 300-600 million. The pulmonary artery also branches extensively and forms a dense network of capillaries which wrap around the alveoli. Air going into the respiratory bronchiole is high [o2] and low [co2: due to simple diffusion, co2 wants to move out of the blood and into the alveoli. 5 factors that maximize simple diffusion across the blood-gas-barrier: short diffusion difference (tiny gap, very large surface area of alveoli (75m2, gradient for diffusion, lipid-soluble substances (co2 and o2, slow blood flow. Boyle"s law: pressure varies inversely with volume chiefly responsible for pulmonary ventilation.

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