PSL201Y1 Final: classifications of hormones
Document Summary
Lecture three: classification of hormones ((peptide/protein = 3+ aas, steroid = cholesterol, amine hormones = single aa) their properties are based largely on their composition. S pre-pro-insulin in the er, released: most hormones, most common, water soluble, dissolved in plasma = into golgi. S released from the golgi as pro- insulin after modification. S cleaved to form active insulin and non-active c-peptide. C-peptide are released into the bloodstream in a 1:1 fashion. S cholesterol is modified by enzymes: water insoluble bound to carriers in the to make steroid hormones. S adrenal cortex = aldosterone, blood long half life (compared to peptide hormones: has cytoplasm/nucleus receptors because it can move among cells, because receptors are at nucleus, can regulate gene expression. Hormone peptide hormone steroid hormone synthesized like proteins. Preprohormone mrna sequence is transcribed with an er signal sequence. Ribosomes translate the prohormone and in the er it undergoes modifications.