BIOB10Y3 Lecture 5: BIOB10 Lecture 5.docx
15 Apr 2012
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Document Summary
Protein starts in the er, sugars are added and modified. Regulated: stored in membrane bound secretory granules till they get a signal to release (correct signal: release of ca from smooth er) When vesicle moves up and fuses with the plasma membrane: exocytosis. >luminal vesicle surface becomes part of cell membrane, anything soluble is released. Vesicle will be directed by rab and snare proteins. Vesicle budding: assemble on the donor membrane, and often bind to receptor that"s used for protein sorting (select components to be packaged. >many triskelion will pinch off and assemble into a basket structure. Copii moves materials forward from er to golgi. Copi coated vesicles transfers materials from tras golgi back to cis golgi (retrieval vesicles) and brings things fro the golgi back to the er. Clathrin moves things to lysosme and cop is involved in the er and golgi. Rab help bring and tether the transport vesicle to the right membrane (often occurs along the cytoskeleton)
