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NSCI 201 Lecture Notes - Cichlid, Barr Body, Hypothalamus

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School
McGill University
Department
Neuroscience
Course
NSCI 201
Professor
Evan Balaban

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Document Summary

Change in sex involves change in gonads, secondary sexual characteristics, and internal changes of the brain. Thus males an females have same dosage of x chromosome: sry: gene for transcription factor that is important in determining whether developing gonad becomes ovary or testes. This is incorrect gonadal tissue is initially bipotent: there is a condition neither male nor female early in dvp. During dvpment, these animals had normal hormone levels for a male. 4 core genotype mice (fcg): delete sry gene from y chromosome, then re-introduce it onto autosome. Cholesterol converted to progesterone, then converted to testosterone: testosterone is substrate from which estrogen is made. 2 important enzymes determine what else is made from testosterone, and distribution of these enzymes is sexually dimorphic. 5-alpha-reducatase: makes hormone that drives differentiation of male secondary sexual characteristics aromatase: make estrogen: many areas inside male brain express aromatase.

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Related Questions

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Select one:

a. Global warming is the only type of climate change.
b. Climate change is beginning to re-draw the map of biomes around the world.
c. Climate change is occurring because the biotic and abiotic parts of ecosystems are not static.
d. Climate change is any substantial change in climate that lasts for an extended period of time.
e. Climate change will likely exceed the ability of many species to adapt and could cause many species to go extinct.

Section 3 - Programming Questions 7. Role playing video games (RPGs) form a loosely defined genre of video games in which the player controls a small number of game characters. These characters form a group of adventurers whose purpose is to fulfill one or many quests. A common feature of RPGs is that the group of adventurers can collect various items and keep them for future me, sach items are added to the player's inventory. In this question, you will write classes which could be used to manage a player's inventory in an RPG. Part 1 Write a class called Item. An Item object represents an entire category of items carried by a group of adventurers, and each Item object has the following attributes: ā€¢ The description of the items in this category (a String) The quantity of tems in this category that the group of adventurers is currently carrying can int). For example, suppose the group of adventurers is carrying 50 Heal Potions and 10 Life Potions. The SO Heal Pations would he represented by a single Item object, the value of the description attribute of this item object would be the string "Heal Potion, and the value of the quantity attribute of this Item object woukl be 50. The 10 Life Potions would also be represented by a single Item object, which is different from the Ttem object representing the Heal Potions. The value of the description attribute of this second Ttem object would he Life Potion", and the value of the quantity attribute of this second liem object would be 10. The Item class MUST provide the following INSTANCE methods, note that in the method descrip tions below, the phrase "this Item" means the item on which the method in question is called ā€¢ A constructor, which takes as its only parameter a string representing the description attribute of the newly created Item. This constructor sets the quantity attribute of the newly created Item to 1. ā€¢ A method called get Description(), which takes no parameters and returns a string representing the value of the description attribute of this Item ā€¢ A method called getQuantity O. which takes no parameters and returns an int represent ing the value of the quantity attribute of this Item ā€¢ A method called set Quantity), which takes a value of type int as its only parameter and returns nothing. This method changes the value of the quantity attribute of this Item so that its new value is equal to the int value this method accepts as parameter, this happens regardless of what the value of the int parameter is, even if it represents a sensical value Note that you MUST respect proper encapsulation practices that is, the attributes and methods of your class MUST he declared using the proper visibility modifiers. Part 2 Write a class called Inventory, which represents the inventory of a group of adventures. An Inventory object has only one attributes a collection of items, which specifies all the types of items that a group of adventurers is currently carrying along with the mumber of items of each type that the group is carrying Inventory objects MUST keep track of the items being carried by adventurers using a PLAIN ARRAY of Items, you MUST NOT se ArrayLists (or any other class which is part of the the Java Collection Framework such as Linkedin.ist) within the Inventory class under ANY circumstances. Each position in the array contains cither ā€¢ The address of an Item object in memory, an Item is considered to be in the Inventory if and only if its address in memory is stored in the array . null Fach Item object in the inventory MUST appear exactly once in this array, in other words, there MUST NOT be any duplicate elements in the array under ANY circumstances, whether these dupli cates are deep copies or aliases The Inventory class MUST provide the following INSTANCE methods, note that an actual im plementation used in an RPG would provide additional methods, in particular methods to add an item to the Inventory. Also note that in the method descriptions below, the phrase "this inventory" means "the Inventory on which the method in question is called ā€¢ A constructor, which takes a value of type int as its only parameter, and initializes the newly created Inventory so that the number of item types it can store is equal to the value of the parameter. The number of item types which can be stored in the Inventory is fixed during instantiation, and can never change during the lifetime of the Inventory object ā€¢ A method called get.Capacity (), which takes no parameters and returns a value of type int representing the capacity of this Inventory (that is, the number of different item types which can be stored in this Inventory). ā€¢ A method called getItem(), which takes a value of type int as its only parameter, and returns the Item Nered at the commenpanding position in the array holding the Items stond in this Inventory, this method returns null if the element at the position specified by the parameter value is null or if the parameter represents an invalid index in this array. ā€¢ A method called consumeOne(), which takes as its only parameter a string represent ing the description of an item, and returns a value of type boolean. The method searches the inventory for an item whose description is equal to the parameter String, with the comparison being performed in a case-INSENSITIVE manner. If no such Ttem exists in the inventory, the method returns false, and the state of the Inventory does not change. On the other hand, if such an Item exist in the inventory, the method returns true and modifies the state of the Inventory as follows: -If the quantity attribute of the item is greater than or equal to 2, then its value is reduced by 1. -If the quantity attribute of the Item is equal to 1, then the item is removed from the Inventory. Note that removing an Item can be done by simply assigning null to the amay position that contains it. The state of the array before and after calling this method can consist of addresses of Item objects interspersed with null elements. For example, in an Inventory whose capacity is 20, it is possible that the array contains the addresses of Item objects al positions 3 and 17. while the other amay position contains null. This implies that the method does NOT have to "compact the array so that the addresses of all the actual tem objects appear at the beginning of the array while all the null elements appear at the end. You MAY assume that the string parameter is not null; in other words, your method does not have to handle cases in which the string parameter is indeed null Akmal notes ā€¢ You MUST respect proper encapulation practices, that is the attributes and methods of your class MUST be declared using the proper visibility modifiers. ā€¢ Y MUNT call the methods you were asked to write in the previous part to retrieve the descrip tion and quantity attributes of an Item object, or to change the quantity attribute of an Item object. You MAY me that the item class has been implemented correctly, even if you did not successfully complete the previous part WRITE YOUR Inventory CLASS IN THE SPACE BELOW:

CASE STUDY
DIVESTITURE IMPLEMENTATION COMMITTEE (DIC) PROJECT
The Divestiture Process
a. Listing of SOEs to be divested
The Government of Ghana provides the Divestiture Implementation Committee (DIC) with a list of enterprises slated for divestiture. DIC opens a file for each such company. All documentation and correspondence prepared or received in
2
connection with the enterprise is placed on this file.
Enterprises listed for divestiture are categorized by the Ministry of Finance (principally on the basis of employee numbers) into small, medium, and large. In most cases, the divestiture of large and medium enterprises is outsourced to consultants. Small enterprises are either outsourced, or divested by DIC.
b. Advertisements
Bid documents are prepared for the particular State Owned Enterprise (SOE), and the SOE is advertised for sale. Adverts should appear in at least 2 leading Ghanaian newspapers each week for 3 consecutive weeks. Adverts may also appear in foreign publications.
c. Bidding
i. Obtaining bid documents
Investors interested in a particular SOE contact the secretariat, and after filling in an application form, paying a non-refundable bid fee (Ā¢1,000 for local investors, and $400 for foreign investors), and signing a confidentiality undertaking, they are provided with the relevant bid documents.
The bid document is made up of
ā€¢ bid procedures;
ā€¢ a draft sale and purchase agreement;
ā€¢ a memorandum containing the profile of the SOE;
ā€¢ an independent valuation report (Ā¢ 1,000 for local investors, and $300 for foreigners);
ā€¢ fixed assets valuation report (where sale of assets is the mode of divestiture);
ā€¢ share valuation report (where sale of shares is the mode of divestiture).
ii. Form of bids
Investors bids should comprise of a qualification statement made up of
1. Details about the bidder, including (as relevant):
a. the bidder's full name, address and contact details;
b. details of the bidder's directors and shareholders;
c. details of the bidder's existing business;
d. financial periods; and
2. The bidder's business plan for the enterprise, including, by way of example:
3
a. plans for the development of the enterprise (with regard to both its rehabilitation and, as relevant, down-sizing of expansion) and the timing of the implementation of those plan;
b. intentions with regard to employment, proposed staff training programmes and proposals for staff participation in the enterprise;
c. marketing approach and initiatives proposed for the enterprise, including export prospects and anticipated opportunities to expand beyond traditional or existing markets;
d. impact on the local community (particularly where the enterprise has traditionally provided social services and/or infrastructure);
e. impact on competition and the regulatory environment; and
f. environment impact;
3. Confirmation that the offer for the assets or, as the case may be, shares of the
enterprise is not subject to any conditions;
a. any important points of principles arising from the draft sale and purchase agreement; and
b. confirmation that the bidder will comply with the bid procedures.
c. The bid procedures must state the requisite contents of the business plan as specifically and clearly as is possible in the circumstances. The details mentioned in 3 above will not be applicable to all enterprises.
4. A price bid.
a. the price offered for the assets or, as the case may be, shares of the enterprise (clearly indicating the proposed currency of payment);
b. if the offer is not on the basis of cash in full on completion, the precise timing of any deferred payments;
c. in the event of deferred payments, details of the security proposed to be given;
d. a detailed explanation of how the bidder intends to finance the acquisition. In the case of an offer made from existing resources, the bidder will be expected to provide written confirmation from its bank or financial adviser that the necessary funds will be available.
In the case of an offer not made from existing resources, the bidder will be expected to provide written confirmation from its arrangers or providers of finance that arrangements have been made, or will be made, to provide the necessary finance; and
5. Confirmation that the bidder has not done, and will not do, at any time any of
the following:
4
a. communicated to a person other than DIC the amount or approximate amount of the price offered (other than in confidence to the bidder's advisers);
b. entered into any arrangement with any other person that he shall refrain from bidding or as to the amount of any price to be offered;
c. offered or agreed to pay or give, or paid or given, any valuable consideration directly or indirectly to any person for doing or having done, or causing or having caused to be done, any act or omission in relation to the price offered by the bidder or any other bid
.
iii. Evaluation of Bids
This is a two stage process:
ā€¢ evaluation of qualification statements; and
ā€¢ comparison of price bids.
DIC opens price bids from only bidders whose qualification statements DIC accepts. In the event of equal price bids, preference is given to Ghanaians.
iv. Rejection of bids :
Bids will be rejected on the following grounds:
ā€¢ received after closing date and time;
ā€¢ appropriate fee not paid;
ā€¢ received from person who canvassed DIC member; and
ā€¢ received from SOE or a body allied to an SOE.
Exceptions under which bids may be accepted include where the assets concerned comprise non-industrial land and buildings, with no on-going business, and the bidding SOE requires additional office accommodation.
d. Negotiations
DIC will write to the winning bidder, and each other bidder, to inform them of the results of the bid.
Negotiations will then start with the winning bidder. Should he fail to satisfy DIC demands, the next highest conforming bidder will be invited to negotiate.
e. Approvals
After DIC Secretariat has agreed the terms of the sale with the winning bidder, the divestiture will be considered by the DIC members.
DIC members, if they are satisfied with the sale, will submit a letter of
5
recommendation to the President's Office for approval.
If either DIC or the President's Office raises concerns concerning the bid, a letter is sent to the bidder and further negotiations may take place.
If the President's Office grants the approval, DIC will send a letter to the bidder inviting him to sign the sale and purchase documentation. The Executive Secretary of DIC will sign on behalf of DIC and the government.
f. Payments
i. Mode of Finance
This could either be with
ā€¢ investors own resource. or
ā€¢ loan from a financial institution (DIC may take security over the asset until full payment is received).
In the case of instalments, for some loans, interest is paid on the diminishing balance.
ii. Terms of Payment
Payment could either be
ā€¢ outright, or
ā€¢ by instalments.
iii. Payment timing
ā€¢ payment of less than 50% of the price offered; or
ā€¢ deferred payment due 3 years after completion.
DIC prefers outright payment, but will consider deferred payment. Deferred considerations should be secured by a guarantee from a bank or other person of sufficient financial standing. If such guarantee is not available, DIC may consider taking security over the assets or, shares of the enterprise until full payment is received.
iv. Interest
Interest on deferred payments is as follows:
ā€¢ Ghanaians: relevant Ghanaian Treasury Bill Rate
ā€¢ Non Ghanaians: relevant London Interbank Offer Rate plus 2%.
v. Divestiture Proceeds
This will be paid to the appropriate DIC bank account.
The Proposed System
The Board of Directors of DIC has received funding from Government of Ghana
6
to commission the development of a robust and user-friendly web-based system that DIC will use for its operations.
REQUIRED:

1. Discuss the system development methodology that you would adopt for this project and justify your choice.
2. Construct data flow diagrams (including a context level diagram, a level 0 diagram, and several child diagrams) that show important, representative parts of the Divestiture Implementation Committee (DIC) System.
3. Identify five data files that will be used in the Divestiture Implementation Committee (DIC) System; and construct a comprehensive Data Dictionary for each of the five data files you have identified.
4. Construct use-case diagrams, sequence diagrams, and class diagrams for the proposed Divestiture Implementation Committee (DIC) System.
5. Construct object diagrams, activity diagrams and communication diagrams for the proposed Divestiture Implementation Committee (DIC) System.
6. Design five reports that should be generated from the Divestiture Implementation Committee (DIC) System.
7. Discuss the testing strategies/techniques that you would use on this project; and provide a table of test criteria and corresponding test data for the testing.