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BIOC21H3 Lecture 5: Lecture 5-Muscle.docx

41 views4 pages
orangemouse642
21 Apr 2012
School
UTSC
Department
Biological Sciences
Course
BIOC21H3
Professor
Stefan Rusyniak

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Document Summary

Muscles are a different type of tissue (3 different types of muscle tissue discussed) Lowest form of organization = myofilaments: actin and myosin filaments are 2 main proteins and organized together to form large bundles = myofibrils. Skeletal muscle cells as muscle fibres (if he talks about muscle fibre = talking about whole cell) Mature muscle cell is myoblast (skeletal muscle; myoblast fuse together to produce myocyte) Sarcosome = muscle cell (but confusing cause use this to refer to mitochondria in muscle cell; won"t use this term frequently) Sarcoplasmic reticulum = used to store calcium ions in muscle fibre. Fibroblasts because muscle tissues closely associated with connective tissue. Purkinje fibre = specialized kind of cardiac fibre *never refer to it as a purkinje cell* Collage type i = because muscle tends to associated with connective tissue. Elastic fibres; some muscle cells can produce these components themselves (blood vessels.

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Related Questions

9-A skeletal muscle develops from the fusion of large number of myoblasts (embryonic muscle forming stem cells). Growth and enlargement of muscles is called________________________ which results from the increase in number of muscle fibers/ activity myosatellite cells persisting in skeletal muscles.

The muscle cells of people with muscular dystrophy lack a protein, called dystrophin, that helps maintain the sarcoplasmic reticulum of muscle cells. as a result, the sarcoplasmic reticulum allows calcium ions to leak out. why would this condition affect muscle function?

Causality1

Learning Goal:

Interpret Causality

Fibroblasts are cells that can be isolated from the connective tissue under the skin and grown in culture. Normally these cells retain the properties of fibroblasts as they divide for many generations in culture, but if we do an experiment in which the fibroblasts are forced to take up a highly expressed copy of the MyoD gene, they rapidly differentiate to become muscle cells.

a) MyoD expression is sufficient to cause fibroblasts to differentiate to muscle cells in culture

b) MyoD expression is correlated with muscle cell differentiation in culture

c) MyoD expression is necessary and sufficient to cause fibroblasts to differentiate to muscle cells in culture

d) MyoD expression is necessary for fibroblasts to differentiate to muscle cells in culture