CSB351Y1 Lecture Notes - Lecture 3: Methionine, Organ Transplantation, Orthomyxoviridae

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grayhedgehog733

4 Apr 2011

School

UTSG

Department

Cell and Systems Biology

Course

CSB351Y1

Professor

Mounir Abou Haidar

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Document Summary

Virus is like a key fitting a lock (cell) --> virus is specific for target cells. Virus has its own glycoprotein attached to it. Only for enveloped virus: envelope of virus: fuses with membrane of cell, virus gets in. Virus replicates once inside the cell--> replication depends on type of virus: The large majority of dna viruses: replicate in the nucleus of the cell (this is where dna/chromosomes are, and where dna-dependent. Rna polymerases are--> function is to synthesize mrna) All dna virus (except for vacinea?) replicate in the nucleus-->go in there, use machinery of cell to make mrna from dna--> mrna goes into cytoplasm to be translated into viral protein. Most dna viruses don"t code for their own dna-dependent rna polymerase, because they know that the cell has them for its own functions. 1 exception: influenza virus -->go to nucleus for replication. Influenza virus wants to make machinery of the cell its slave!

Related Questions

Orthomyxoviruses (influenza) and picornaviruses (polio) are both RNA viruses that encode their own RNA polymerase. However, Orthomyxoviruses mRNA synthesis requires the activity of the host RNA polymerase II, whereas picornavirus mRNA synthesis does not. Discuss this observation in the context of the two basic types of priming mechanism used by RNA-dependent RNA polymerases?

Mechanisms ==> 1-protein-linked oligonucleotide. 2- Cap-snatching

1- An early test to determine if a virus was causing an illnessinvolved passing filtered fluid from one host to the next aftergreat dilution. What did this approach (serial dilution)demonstrate about the agent causing the illness?

2- what is the difference between the eclipse phase and thelatent phase of the virus replication cycle?

3- How are virus capsid proteins limited by the coding potentialof their nucliec acid, and how do they overcome thislimitations?

4- You are working in a lab and isolate a brand new virus. Youanalyze the nucleotide composition and determine the bases are inthe following proportions:

G: 30% T: 40% C:20% A:10% what type and strandedness of nucleicacid does it likely contain? what Baltimore class is it?

5- What is the difference between a satellite nucleic acid and aviroid?

6- Explain how an enveloped virus enters a cell by fusion.

7- What are the three functions of enzyme reversetranscriptase?

8- Some RNA viruses don't package an RNA-dependent RNApolymerase in their particle. How do they replicate? what typ ofvirus does this (nucleic acid type, strandedness, and sense)?

bluebear718

Virology: The Infected Cell

1. How is poliovirus mRNA translated if viral infection leads to inhibition of 5â-end dependent translation?

2. What is the purpose of the cell inhibiting translation during virus infection? How is this inhibition accomplished? How is it overcome to allow viral protein synthesis?

3. How are glycolysis, fatty acid metabolism, and the TCA cycle manipulation to favor viral replication?

CSB351Y1 Lecture Notes - Lecture 3: Methionine, Organ Transplantation, Orthomyxoviridae

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