MIMM 314 Study Guide - Complement Factor B, Collagen, Complement Component 4

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Heat-labile component of normal plasma that augments the opsonization and killing of bacteria by antibodies. Complement can also be activated early in infection in the absence of antibodies. Complement first evolved as part of the innate immune system, where it has an important role in coating pathogens and facilitating their destruction. 2-11: complement is a system of plasma proteins that is activated by the presence of pathogens. Complement system is made up of a large number of diff plasma prot that interact with one another both to opsonize pathogens and to induce a series of imfammatory responses that help to fight infec. Several complement prot are preateases that become activated only after cleavage, usually by another specific protease. In their inactive form --> called pro-enzymes or zymogens. At sites of infec, they are locally activated by the presence of he pathogen and trigger a series of powerful inflammatory events.

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