MIMM 413 Lecture : jan 30 2012- dr. olivier.docx

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Chagas disease caused by t. cruzi, only found in south america. Mainly in brazil, and a little in peru and equador as well as the north of argentina and chile. The difference between this and leishmania is that the amastigote and promastigote is usually found in leishmania, but here is the trypomastogote and the epimastigote. The amastigote and trypomastigote is in the host, and the epimastigote form is in the vector. So in trypanosoma you have the epimastogote, amastigote, and trypomastigote form (compared to the two in leishmania). To differentiate them: the kinetoplasm is where the flagella starts. In the trypomastigote, you have the kinteoplast (black dot) on the posterior side of the parasite. Where the flagella goes out is the front of the parasite. In the epimastigote, the nucleus and the kinetoplast are on the same side. In the promastigote, the nucleus is in the center and the kinetoplast is at the anterior part.

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