BIO130H1 Lecture Notes - Lecture 6: Antiporter, Osmosis, Nuclear Pore
31
BIO130H1 Full Course Notes
Verified Note
31 documents
Document Summary
Transmembrane proteins span both the cytosol and er lumen sides. Have a hydrophopic stop sequence, hydrophilic end (cytosol site, interact w aq) Rna conerted to protein in cytosolic ribosomes, co-translational translocation. Signal sequence (n-terminus end) attaches to translocator protein. Protein is fed into er until translocator protein reaches stop-transfer sequence. Transmembrane protein has different orientation if signal sequence is internal: More positive aa side faces cytosol, negative side faces er lumen. Co-translational tranlocation, n/c-termius both face one side, depends on charge. Start and stop sequence both embedded in er membrane. *the translocator open laterally and the protein. Definition: the golgi apparatus receives proteins and lipids from the endoplasmic reticulum, modifies them(glycosylation), and then dispatches them to other destinations in the cell by vesicular form. Protein bud off from er, fuse w cis golgi, then move through individual cisterna by budding of and fusing to trans cisterna. The reason for this is: glycosylation is complex, it requires several enzymes.
