KIN217 Study Guide - Lipidomics, Molecular Recognition, Sickle-Cell Disease
Document Summary
Once they have been synthesized they fold into defined 3d structures. Dehydration rxn losing water (carboxyl and amine group, lose water dipeptide bond) Catalysis of rxn by enzyme proteins is central to the existence of life. Esseentially all events that occur in cells require a protein or proteins. Usually one protein catalyses a single rxn o. 20 aa x (35-several thousands in length) = a lot of possibilities. Semiconservative (separation of strands and synthesis of individ strands) 4 x 4x 4 = 64 diff combinations. Dna mrna polypeptide folded protein. Proteins may contain more than 1 polypeptide chain. Changes in the dna (mutations) result in changes in protein structure. Rare occasions when a favourable mutation occurs the organism is advantaged and selection occurs. Gene duplication allows mutation to occur in a way that is less likely to disadvantage the organism. Ie: being heterozygous for sickle cell anemia makes you immune to malaria. Ie: diabetes in cold temp, protect against frostbite.
