HMB200H1 Lecture 18: Lecture 18
Document Summary
Announcement: ramsay wright on march 30 sheep brains. Increased activity in amygdala, mediodorsal thal, medial orbitofrontal cortex. Benzodiazepines inhibit amygdala & many other areas: act on gabaa recs (most neurons in brain = gaba) so. Electroconvulsive therapy blocks depression quickly best across frontal areas. Remote long term memories affected by ect and cingulate lesions. Genes & depression: women more susceptible by 2x for depr and anxiety. Also, activate hypothalamus feeding/energy system for weight loss: produce long term effects in brain evaluation as well as anxiety, reduce activity in limbic-frontal cortex areas, antidepressants slowly increase synapse growth (ex. in. Increase energy by activity hypothal feeding & energy centres dentate gyrus) & neurogenesis slow therapeutic action; led to by serotonin increase but not clear how. Improves longterm thinking about problems: act on old limbic systems that produce irrational thoughts. Cognitive therapy inhibits other frontal areas: more effective together w ssris. Electroconvulsive shock still used occasionally, e. g. suicide, poor drug effect.