CSB332H1 Lecture Notes - Stephen Kuffler, Ganglion Cell, Ganglion

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coppercattle724

16 Aug 2012

School

UTSG

Department

Cell and Systems Biology

Course

CSB332H1

Professor

Melanie Woodin

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Document Summary

D & h bipolars not only responding to light. Tell the cns about small spots of light surrounded by dark (& vice versa) Essentially responding to contrasting patterns of light & dark over small patch of retina. Aps evoked in on ganglion cells by small spots of light shone onto center of field surrounded by darkness. Aps evoked in off ganglion cells by small dark spots surrounded by light. Rfs of ganglions 1st characterized by stephen kuffler in 1950s. Eyes of anesthetized cat focused on screen w various patterns of light generated by computer. Electrode records responses from single cell in visual pathway. Rf for ganglion determined by correlating area of screen illuminated w neuron"s firing. Ganglions normally fire aps even at rest. Rf mapped by correlating light shone on retina w increases or decreases in ap firing of ganglion. 2 main grps of ganglions: on & off centre fields.

Related Questions

Vision

You are testing a variety of vision altering drugs by monitoring the electrical and chemical activity within a photorecptor and their associated bipolar and gaglion cells. Upon light stimulation you can record the graded ptentioal within the bipolar cell and the graded and action potential within the ganglion cells. You can also monitor the activation and conversion of all of the critical molecules in the light transduction pathway= this is normal activity. Upon the addition of your drugs you observe the following:

A.) Upon application of drug "Bazinga" to your preparation, in the absence of any light, you observe activity in the bipolar and ganglion cells, even though cGMP-PDE is still inactive. Please give as many hypotheses and their explinations as to how "Bazinga" was able to cause this effect.

B.)Upon application of drug "PSY" to your preparation and stimulated with normal levels of light, your discover that the level of neural activity in the rod's bipolar and ganglion cells are reduced significantly, while the neuronal activity in the cone's bipolar and ganglion cell is zero. Please give as many hypotheses and their explinations in detail as to how compound "PSY" caused its effects.

When you move your eyes up and down at high speed, those movements are initiated by neurons in the _________. However, high speed side-to-side movements are due to neurons in the pons and medulla.

A.) pons

B.) parotid gland

C.) central ganglia

D.) midbrain

The neurons of the retina that sense light include: (choose all that apply)

A.) Rods

B.) Amacrine cells

C.) Cones

D.) Bipolar cells

E.) Optic nerve cells

burgundymole266

1. During a routine neurologic examination of a 27-year-old woman, the physician discovers what is called a âblind spotâ (also called a physiologic scotoma) in the visual field of this patient. Which of the following most specifically explains this observation?

a. A small scotoma resultant to a retinal detachment

b. Occlusion of the central retinal artery

c. A visual defect resulting from an increase in intracranial pressure transmitted along the subarachnoid space surrounding the optic nerve

d. A spot in the visual field corresponding to the optic disc where there are no rods, cones, or ganglion cells

e. A visual defect corresponding to a lesion of the crossing fibers of the optic chiasm

2. Describe the clinical significance of limbic system. Why is it called an emotional brain? Is there any gender-based difference?

CSB332H1 Lecture Notes - Stephen Kuffler, Ganglion Cell, Ganglion

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