BIOB10Y3 Lecture Notes - Marshall Warren Nirenberg, Sickle-Cell Disease, Phenylalanine

81 views2 pages
27 Sep 2012
School
Course
Professor

Document Summary

How is the info in nucleic acids (dna, then mrna) converted into the order of amino acids incorporated to build a protein: genetic code. Discovered that 3 nucleotides likely specified the code" for a single amino acid these nucleotides or codons are non-overlapping. Examining the outcome of diseases such as sickle cell anemia (single base substitution) revealed that the code is non-overlapping. Only affected one amino acid = one codon the genetic code is degenerate. 64 possible codons encode 20 amino acids and stop". More than one codon per type of amino acid. Incubated this with bacterial extract (contains all amino acids and factors necessary for protein synthesis) Marshall nirenberg and colleagues synthesized an mrna in vitro solely made up of u"s poly(u) Examined the new polypeptide synthesized it was polyphenylalanine. By similar methods, the coding specificities of each of the 64 codons was discovered.

Get access

Grade+20% off
$8 USD/m$10 USD/m
Billed $96 USD annually
Grade+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
40 Verified Answers
Class+
$8 USD/m
Billed $96 USD annually
Class+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
30 Verified Answers

Related Documents

Related Questions