BIOL 2021 Lecture Notes - Lecture 12: Cytosol, Aspirin, Membrane Transport Protein
11 Oct 2012
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Document Summary
G-protein coupled receptors gpcr g-protein coupled receptors largest family in cell surface. Amplification -> a small signal can go and activate many other g-proteins. Ligand binding site outside g-protein binding site inside. B-bound as a peripheral protein to and . Specific for a particular gpcr and for a target. Guanine nucleotide exchange factor (gef) in the gpcr activating protein/factor. Active receptor is going to cause a conformational (alpha subunit) of g-protein change to give an active. And then you exchange the gdp for gtp and then it is activated. The target that it activates are ion channels or enzymes. End signal (inactivates) alpha subunit has gtpase activity. Arrestin protein binds and prevents activating any other g-proteins. Alpha, beta, gamma when they are all inactive they are all together. Alpha dissociates and beta nand gamma are together these are both active. Bind gdp alpha, beta, gamma come back together become inactive.
