PSYC62H3 Lecture Notes - Nucleus Accumbens, Behavioral Addiction, Reinforcement
Document Summary
Drug tolerance: reduction in potency or efficacy of a drug with repeated administration. Increasingly larger doses of the drug are required to induce the same behavioural effect. Tolerance due to drug exposure is different from genetic or dispositional tolerance> individual isn"t affected by the drug as much as others bc of genetic or dispositional factors. Tachyphylaxis or acute tolerance: same amount of drug administered on two separate occasions a couple of hours apart may induce greater effects with the first dose than with the second dose. Cross-tolerance: development of tolerance for one type of drug results in decreased sensitivity to effects of another type of drug. Once tolerance to a drug develops, larger and more frequent doses that do become toxic are often administered. Tolerance to the effects of drugs do not develop uniformly. Drug sensitization: increase in potency or efficacy with repeated administration.
