CSB351Y1 Midterm: TERM TEST 1 NOTES

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Lecture 2 & 3 composition of viruses. In general, viruses are composed of either rna or dna (never both) and are covered by one or several types of protein. Nucleic acids + proteins in viruses are not covalently linked, but stabilized by hydrogen, ionic, van der waals, hydrophobic, and other weak bonds. Formed of 3 types: heterocyclic nitrogenous base, a sugar, a phosphate. Dna: a g c t; deoxyribose (2"c) Glycosidic bond links nh-group in position 9 of purines and position 1 of pyrimidines to position 1" of the sugar. The phosphates link the bases on the sugar in positions 3" and 5" (ester bond) Cg has 3 bonds -> more stable and stronger. Dna and rna polymerases: necessary for viral replication, add a nucleotide to the 3" oh end of a growing strand of dna or rna, sequence determined by template strand of dna/rna. Rna polymerase do not require a primer.

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