CSB327H1 Lecture Notes - Lecture 13: Timp2, Hemopexin, Tissue Inhibitor Of Metalloproteinase
19 Nov 2012
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Csb327 lecture 13 notes (november 5, 2012) mmps and adams. 2 outline: mmps breakdown stuff, this lecture is about the dynamic interplay between mmps, fa, and matrix turnover, we do not make activated mmps in our tissues. We do not make a lot in our normal tissue. You make mmps in response to tissue injury, tumour progression and invasion, and embryogenesis. 3 mmp substrates identified in complex biological samples by proteomic analysis: Without regulating this symphony of signaling with these mmps, this just falls apart. The hemopexin domain and the fn domain help you target a specific molecule in the ecm or ecm component: the cys in the pro-domain will interact with zn2+ in the catalytic domain. There is an intimate contact with the cys and zn2+. The mmp is inactive: fn type ii domain is essential for gelatinases to cleave gelatin, gelatin is broken down collagen, collagenases can only target intact collagen fibrils.
