EDKP 395 Lecture Notes - Lecture 3: Malate Dehydrogenase, Succinate Dehydrogenase, Acetyl-Coa

• School: McGill University
• Department: Kinesiology&Physical Education
• Course: EDKP 395
• Professor: Russell T Hepple

Document Summary

Invented by hans krebs: rejected the first 2x he presented his theory. Main function is to remove hydrogen and associated energy bond b/w hydrogen and various substrates involved in kreb cycle: h+ contain the pe in food molecules. Enzymes found in mitochondrial matrix citrate synthase enzyme: electron transport is found in cortex. Process: pyruvic acid (3c) is converted to acetyl-coa (2c) Co2 is produced: acetyl-coa combines with oxaloacetate (4c) to form citrate (6c) Enzyme citrate synthase catalyzes this event: citrate is metabolized into oxaloacetate. Cyclic procedure due to reformation of oxaloacetate. Products during each kreb cycle: 3 molecules of nadh. 2. 5 atp"s formed formed at 3 different places isocitrate isocitrate dehydrogenase alpha ketoglutarate. Malate malate dehydrogenase oxaloacetate: 1 molecule fadh2. 1. 5 atp"s formed for 1 fadh molecule. Nadh >>> fadh2 in terms of richness of energy (how many atp"s form from 1 molecule) Fumarate: 1 molecule gtp formation is called substrate-level phosphorylation .