EDKP 395 Lecture Notes - Lecture 6: Gas Exchange, Pulmonary Edema, Muscles Of Respiration

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Exercise induced increase in vo2 and vco2 causes blood returning to lungs from exercising muscle to get progressively more: hypoxic. Decrease po2, sao2 (arterial o2 saturation), cvo2: hypercapnic/acidic. This disturbs acid base balance and compromises o2 delivery via hypoxic state. Ventilatory requirements 20-30x above resting levels must be met while minimizing the o2 cost of breathing/mechanical work (i. e. most efficient way possible: this requires. Feed forward & feedback control mechanisms to ensure ventilatory response to exercise is driven in proportion to muscle metabolic requirements (vco2, vo2) Note: at rest respiratory system is extremely efficient less energy used than is needed to power a lightbulb. The work produced by both locomotor and respiratory muscles increase several fold during exercise: blood flow/o2 requirements of both sets of muscles must be met. Excessive work and o2 cost of breathing will steal blood flow away from exercising muscle located in ideal position to do this. Leads to muscle fatigue: respiratory muscles important skeletal muscle.

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