PSYC 208 Study Guide - Midterm Guide: Isaac Newton, Bertrand Russell, Frontal Lobe
Document Summary
Concordance rates: mz twins:48 % and dz twins:17% If both parents have schizophrenia:46% chance for offspring. Genes involved in regulaition of dopamine and serotonin activity. Polymorphism of neurotophins (proteins) involved in synapse creation and pruning, and neuron development and survival. Genes are not enough, in cognition with environment. Exposure to influenza and other viruses during second trimester. Urban environments, more stressful, higher paced life can cause schizophrenia. Immigration, people who immigrate have small increase in schizophrenia. Indivi who develop schizophrenia later in life often are seen to use cannabis. Can cause extra pressure in brain and cause death of neurons. Reduced gray matter (prefrontal and temporal lobes) where the social cognition is. Increased dopamine production in the midbrain (positive symptoms) Decreased dopamine activity in the prefrontal lobe (negative symptoms) Single psychotic episode with remission and favorable outcome: 20-30% Multiple episodes with (partial) remission in between: 30% Chronic deteriorating course with increasing negative symptoms: 33%. require constant care.
