BIOL 102 Lecture Notes - Isotopes Of Nitrogen, Alkaptonuria, Post-Translational Modification
20 Nov 2012
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Meselsohn and stahl bacteria take up any isotope of n to make dna. Used heavy n (15n) instead of normal n (14n) to make heavy dna in bacteria; several generation. Then provided with 14 n containing medium in later generations of growth. Alkaptonuria or black urine homogentisic acid in urine oxidizes and turns dark. Response elements regulatory elements - dna sequences that regulate genes. Bind regulatory proteins that control transcription at core promoter. Preinitiation complex rna polymerase, 5 different general transcription factors (gtfs), gtfs and rna polymerase must come together at core promoter. Posttranslational modification insulin pancreas within the beta cells of islets of. Checkpoint protein p53 is a g1 checkpoint protein; p53 is induced when dna is damaged. Then cell cannot progress from g1 to the s, or synthesis, phase of the cell cycle. About 50% of all human cancers are associated with defects in p53 gene.
