Physiology 4700A/B Lecture Notes - Hippocampus Anatomy, Temporal Lobe Epilepsy, Calbindin
20 Nov 2012
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Dendritic but not somatic gabaergic inhibition is decreased in experimental epilepsy: cossart, c. dinocourt, j. c. hirsch, a. merchan-perez, j. De felipe, y. ben-ari, m. esclapez and c. Note: the last section of the document illustrates the important neural circuits and briefly explains the application of ttx. Temporal lobe epilepsy (tle) is the most common form of epilepsy in adults. It is a type of partial (focal) seizure that originates in the temporal lobe. Abnormalities of the temporal lobe are associated with vivid perception of colours and emotional responses because it has a strong connection with the limbic system mediated by the entorhinal cortex (ec) - remember: van gogh! Temporal lobe epilepsy is associated with neuronal cell loss and axonal sprouting in the hippocampus. Cossart et al. aimed to better characterize neuronal cell loss and gabaergic synapse reorganization in the hippocampus, primarily in the ca1 region. They used brain slices from rats exposed to kainate and pilocarpine, both excitatory agonists.
