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MCGILLMIMM 211Benoit CousineauFall

MIMM 211 Lecture Notes - Lecture 13: Dna Polymerase Iii Holoenzyme, Dna Mismatch Repair, Dna Repair

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13 Dec 2018
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These two enzymes follow the replication fork on the newly synthesised dsdna and scan for mismatches. Bacterial cells methylate their dna which is usef
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MCGILLMIMM 211Benoit CousineauFall

MIMM 211 Lecture Notes - Lecture 12: Transfer Rna, Pyrimidine Dimer, Exonuclease

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13 Dec 2018
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The dna sequence (4nts) needs to code for 20 different aas. A codon cannot be shorter than 3 nucleotides in length. The code is degenerate there is mor
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MCGILLMIMM 211Benoit CousineauFall

MIMM 211 Lecture Notes - Lecture 11: Ribosomal Rna, Transfer Rna, Cistron

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13 Dec 2018
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**announcement from prof: mistake in the following slide. When it gets synthesised, it becomes a penta-peptide. Hence, the addition of another d-alanin
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MCGILLMIMM 211Benoit CousineauFall

MIMM 211 Lecture Notes - Lecture 15: Research In Computational Molecular Biology, Bacterial Conjugation, Tata Xover

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13 Dec 2018
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Bacterial plasmids and genetic exchange: we will see, general principles, bacterial recbom (genetic variability, bacterial plasmids, bacterial horizont
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MCGILLMIMM 211Benoit CousineauFall

MIMM 211 Lecture Notes - Lecture 14: Start Codon, Transfer Rna, Genetic Code

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13 Dec 2018
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Here, the 5" end is on the left (be careful bc it will not always be drawn the same) The aa is loaded onto the last a of the cca. The anticodon triplet
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MCGILLMIMM 211Benoit CousineauFall

MIMM 211 Lecture Notes - Lecture 6: Mitochondrion, Prokaryote, Chloroplast

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13 Dec 2018
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Tiny eukaryote: nanochlorum eukaryotum (a green alga) We will look at the morphology of the prokaryotic cell. Not all cells have all of these character
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MCGILLMIMM 211Benoit CousineauFall

MIMM 211 Lecture Notes - Lecture 7: Periplasm, Ribitol, Peptidoglycan

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13 Dec 2018
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In gram +ve cells, the cell wall also contains teichoic acid (glycerol or ribitol polymers) that runs perpendicular to the peptidoglycan chains: acts t
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MCGILLMIMM 211Benoit CousineauFall

MIMM 211 Lecture Notes - Lecture 9: Streptococcus Pyogenes, Saccharomyces, Microbiological Culture

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13 Dec 2018
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**prof shows us video of binary fission of s. pyogenes. It is important to note that these long chains don"t just grow from the outside, they are getti
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MCGILLMIMM 211Benoit CousineauFall

MIMM 211 Lecture Notes - Lecture 8: Gram-Negative Bacteria, The Membranes, Cytoskeleton

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13 Dec 2018
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**student question about how the iron gets into bacterial cells. These bacteria have specific transporters on their surface. Iron is such a small molec
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MCGILLMIMM 211Benoit CousineauFall

MIMM 211 Lecture Notes - Lecture 10: Superoxide, Turbidity, Uracil

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13 Dec 2018
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When you put bacteria in non-optimal ph, they will either not grow very well or not at all. Not the gap at the bottom of the table. Oxygen produces tox
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MCGILLMIMM 211Benoit CousineauFall

MIMM 211 Lecture Notes - Lecture 5: Diplococcus, Spirillum, Bacilli

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13 Dec 2018
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Shape and arrangement of cells: spherical or ellipsoidal cells, cocci (singular, coccus, cylindrical or rodlike, bacilli (singular, bacillus, helical o
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MCGILLMIMM 211Benoit CousineauFall

MIMM 211 Lecture Notes - Lecture 3: Phylogenetic Tree, Coevolution, Bacterial Taxonomy

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13 Dec 2018
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MCGILLMIMM 211Benoit CousineauFall

MIMM 211 Lecture Notes - Lecture 4: Lactococcus Lactis, Campylobacter Jejuni, Helicobacter Pylori

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13 Dec 2018
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MCGILLMIMM 211Benoit CousineauFall

MIMM 211 Lecture Notes - Lecture 2: Lazzaro Spallanzani, Francesco Redi, Beer Engine

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13 Dec 2018
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Spontaneous generation: recall that in 1665, francesco redi showed that fly larvae can only develop in meat that the fly can reach, he claimed that his
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MCGILLMIMM 211Benoit CousineauFall

MIMM 211 Lecture Notes - Lecture 1: Lyman Duff, Mcgraw-Hill Education, Parasitology

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13 Dec 2018
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Professor: dr. benoit cousineau: lyman duff medical room 617, benoit. cousineau@mcgill. ca. Tas: felix laroche-johnston (phd candidate, felix. laroche-
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MCGILLMIMM 211Benoit CousineauFall

MIMM 211 Lecture Notes - Lecture 26: Pathogenic Bacteria, Streptococcal Pharyngitis, Clostridium Tetani

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13 Dec 2018
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Context and rationale for studying bacterial pathogenesis. Overview of the steps involved in bacterial infection. Bacterial pathogens cause a wide rang
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MCGILLMIMM 211Benoit CousineauFall

MIMM 211 Lecture Notes - Lecture 31: Minimum Inhibitory Concentration, Petri Dish, Multiple Drug Resistance

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13 Dec 2018
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Mimm 211 antimicrobial chemotherapy: compounds & resistance ii (11/21/18) Abx resistance is a crisis and is on the rise. Reports by both the cdc and wh
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MCGILLMIMM 211Benoit CousineauFall

MIMM 211 Lecture Notes - Lecture 27: Stanley Falkow, Shigatoxigenic And Verotoxigenic Escherichia Coli, Listeria

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13 Dec 2018
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Bacterial virulence factors: definitions, acquisition, examples. Two examples of bacterial pathogens: enterohemorrhagic e. coli, an extracell diarrhoea
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MCGILLMIMM 211Benoit CousineauFall

MIMM 211 Lecture Notes - Lecture 30: Streptococcal Pharyngitis, Aureus, Chemotherapy

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13 Dec 2018
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Mimm 211 antimicrobial chemotherapy: compounds & resistance (11/19/18) If we are not careful, we will soon be in a post-abx era and for some patients a
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MCGILLMIMM 211Benoit CousineauFall

MIMM 211 Lecture Notes - Lecture 28: Food Spoilage, Foodborne Illness, Campylobacter

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13 Dec 2018
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Most things that we talk about today are broadly antimicrobial which means that they can target bacteria, viruses and fungi. There are limitations in o
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MCGILLMIMM 211Benoit CousineauFall

MIMM 211 Lecture Notes - Lecture 29: Joint Replacement, Heart Transplantation, Povidone-Iodine

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13 Dec 2018
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If it was industrial level processing, we would probably use gamma radiation: no heat involved, no pressure, no chemicals, nothing to denature the prot
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MCGILLMIMM 211Benoit CousineauFall

MIMM 211 Lecture Notes - Lecture 25: Leishmaniasis, Parasitic Disease, Protozoa

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13 Dec 2018
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Prof mentions that he doesn"t like this slide for one reason: there is an omission. Leishmaniasis was omitted from the previous slide. It is transmitte
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MCGILLMIMM 211Benoit CousineauFall

MIMM 211 Lecture Notes - Lecture 22: Human Microbiota, Axenic, Dysbiosis

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13 Dec 2018
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Most studies only show an association or correlation: certain types of microbes/microbial genes tend to be more present in certain types of diseases. N
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MCGILLMIMM 211Benoit CousineauFall

MIMM 211 Lecture Notes - Lecture 21: Louis Pasteur, Human Microbiota, Animalcule

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13 Dec 2018
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Next lecture: the human microbiome, health and disease. Friday"s lecture: the other members of the microbiome. This represents a pubmed search for huma
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MCGILLMIMM 211Benoit CousineauFall

MIMM 211 Lecture Notes - Lecture 23: Human Microbiota, Dysbiosis, Probiotic

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13 Dec 2018
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Whole-body effects and manipulating the microbiome for health. Correlation between altered microbiota and ibd, malnutrition, stunting, liver disease, c
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MCGILLMIMM 211Benoit CousineauFall

MIMM 211 Lecture Notes - Lecture 24: Sputum, Volvulus, Schistosomiasis

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13 Dec 2018
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Unlike bacteria and viruses, parasites have a nucleus, larger genomes and more complicated cellular structure: they are eukaryotes. Unlike bacteria or
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MCGILLMIMM 211Benoit CousineauFall

MIMM 211 Lecture Notes - Lecture 17: Omphalotus Olearius, Phallus Impudicus, Phallaceae

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13 Dec 2018
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Mimm 211 - mycology w/ prof turcotte (10/17/18) Jack-o-lantern mushroom omphalotus olearius: north american basidiomycete, produces fruiting bodies on
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MCGILLMIMM 211Benoit CousineauFall

MIMM 211 Lecture Notes - Lecture 16: Diabetes Mellitus Type 1, Mycology, Lisa Lopes

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13 Dec 2018
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Mimm 211 mycology w/ prof turcotte (10/15/18) Intro: terms, taxonomy, life cycles: plant mycology, medical mycology, toxins and biosynthesis, note that
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MCGILLMIMM 211Benoit CousineauFall

MIMM 211 Lecture Notes - Lecture 19: Onychomycosis, Athlete'S Foot, Trichophyton Interdigitale

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13 Dec 2018
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Mimm 211 - mycology w/ prof turcotte (10/24/18) **note about chytrids from lecture 17 both the asexual spores and sexual gametes (2n) are motile. These
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MCGILLMIMM 211Benoit CousineauFall

MIMM 211 Lecture Notes - Lecture 18: Mycology, Mushroom Poisoning, Aspergillus

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13 Dec 2018
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Mimm 211 - mycology w/ prof turcotte (10/19/18) Hypersensitivity allergy: the compounds that fungi secrete in order to digest organisms are powerful al
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MCGILLMIMM 211Benoit CousineauFall

MIMM 211 Lecture Notes - Lecture 20: Wallpaper Paste, Arsenic Poisoning, Mycology

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13 Dec 2018
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The musee des beaux-arts has the highest number of napoleon artifacts. Due to the contributions of ben wheeler: parents came from poland and settled in
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MCGILLPATH 300Edith ZorychtaWinter

PATH 300 Lecture Notes - Lecture 21: Point Mutation, Retina, Sarcoma

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10 Apr 2018
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MCGILLBIOL 301Hugo ZhengWinter

BIOL 301 Lecture Notes - Lecture 10: Chemiluminescence, Kimberly-Clark, Coomassie Brilliant Blue

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10 Apr 2018
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Biol 301 laboratory #10: identification of proteins resolved in page gels. **note that the first 10 steps are performed by the lab tech. Discard last w
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MCGILLBIOL 301Hugo ZhengWinter

BIOL 301 Lecture Notes - Lecture 9: Gasket, Filter Paper, Biological Hazard

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10 Apr 2018
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Biol 301 laboratory #9: polyacrylamide gels and protein characterisation. Protein sample preparation and loading on 1d sds-page gel. Thaw protein sampl
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MCGILLBIOL 301Hugo ZhengWinter

BIOL 301 Lecture Notes - Lecture 8: P200, Affinity Chromatography, Cuvette

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10 Apr 2018
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MCGILLPATH 300Edith ZorychtaWinter

PATH 300 Lecture Notes - Lecture 18: Congenital Disorder, Cerebrovascular Disease, Neoplasm

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2 Apr 2018
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Announcements: this week dr. zorychta is having sessions with those who scored 50% on the midterm, email dr. zorychta for remedial help sessions, and e
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MCGILLPATH 300Edith ZorychtaWinter

PATH 300 Lecture Notes - Lecture 15: Atrioventricular Node, Purkinje Fibers, Sinoatrial Node

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2 Apr 2018
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Insulation between the atria and the ventricles: the conduction is very controlled so the atria contract first before the delay, then the ventricles co
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MCGILLPATH 300Edith ZorychtaWinter

PATH 300 Lecture Notes - Lecture 14: Cardiovascular Disease, Diastole, Blood Pressures

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2 Apr 2018
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MCGILLPATH 300Edith ZorychtaWinter

PATH 300 Lecture Notes - Lecture 16: Mucociliary Clearance, Cellular Respiration, Trachea

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2 Apr 2018
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Airways are covered by a thin layer of mucus propelled by the cilia. Particles, pathogens, and foreign objects that are inhaled get trapped and coughed
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MCGILLPATH 300Edith ZorychtaWinter

PATH 300 Lecture Notes - Lecture 20: Bronchus, Sedentary Lifestyle, 8 Women

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2 Apr 2018
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Most common cancers: the most common cancers are breast and prostate, and there are good survival rates. Many people will survive these 2 types of canc
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