teacherreco

teacherreco

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recoSt. Scholastica's College

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Hello there, My name is Teacher Reco. I studied for, a Bachelor of Science in Nursing. I'm a teacher too. I'm an online teacher for almost 3 years. In my free time I love readi...

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Cellular Neuroscience Study Questions

A. What are the different types of I/V curves (rectifying, non-rectifying; through 0,0, not through 0,0) and their meanings.
B. What is the Nernst Equation and how does it pertains to the equilibrium potential for an ion.
C. What is Driving Force and the formula used to calculate it. How is it the force that pushes ions through an electrical circuit.
D. What is the Equivalent Circuit Equation and the variables that it uses, Ix, gx, Vm and Ex. How can it be used to calculate Vm.
E. What is the GHK Equation and the variables that it uses, Vm, [X]i, [X]o, Px, and Ei. How it can be used to calculate Vm. Note that Px and gx are similar but not the same. Also note that the GHK Equation simplifies to the Nernst Equation if only one ion is involved.
F. How does Vm changes systematically with [K]o or [K]i. Note that Vm graphs linearly with [K]o if [K]o is on a logarithmic scale. Why? What is the slope of this relationship?
G. How do you calculate total memberane resistance, total internal resistance and total membrane capacitance given appropriate values for rm, ri and cm.
H. Understand the equations that describe passive decay of Vm with distance and with time. Have an intuitive sense of how these equations operate.
I. What is the length constant. Why does passive electrical signals decay with distance. Why does rm and ri help determine length constant.
J. What is the time constant. why does passive electrical signals decay with time. why does rm and cm help determine time constant. What is the equation for time constant.
K. how are rm, ri and cm are affected by the diameter of an axon.
L. how rm (and cm) change with myelination of an axon and how these changes can affect lenght constant and conduction velocity.
M. why and how the conduction velocity changes when axoplasm is squeezed from an axon.
N. Understand how the voltage clamp operates and what benefits it confers experimentally. Understand the I vs t traces and I/V curve for the leakage channels. Understand the capacitative current, IC, and how it’s different from ionic current, Ii.

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