HAY 309 Study Guide - Final Guide: Genetic Predisposition, Temporal Lobe, Parahippocampal Gyrus
Document Summary
What physiological factors may lead to disturbances of thought and behaviour? (e. g. drug, metabolic disturbance, neurological pathology) Psychosis (cid:272)o(cid:374)ditio(cid:374) that affe(cid:272)ts perso(cid:374)(cid:859)s (cid:373)i(cid:374)d a(cid:374)d (cid:373)e(cid:374)tal state. Possible causes of altered mind and mental state. Structural abnormalities: temporal cortex (superior temporal gyrus, parahippocampal gyrus, hippocampus, amygdala, frontal cortex. Few hypotheses that might be the causes of psychosis. D2-receptor antagonism and more potent 5-ht2a-receptor blockade: glutamate is the major excitatory neurotransmitter in the brain, phencyclidine and ketamine are noncompetitive inhibitors of the nmda receptor that exacerbate both cognitive impairment and psychosis in. In behavioral tests, ampakines are effective in correcting behaviors in various animal models of schizophrenia and depression: they protect neurons against neurotoxic insults, in part by mobilizing growth factors such as brain-derived neurotrophic factor (bdnf). Psychoactive drugs: cannabis, cocaine, amphetamines, cathinones, lsd, k opioid receptor agonists, nmda receptor antagonists (ketamine)
