IMED3001 Study Guide - Midterm Guide: Natriuretic Peptide, Natriuresis, Endothelin
Imed3001: natriuretic peptides: renin angiotensin aldosterone system (raas) Increased tissue ace activity and angiotensinogen levels. Arginine vasopressin (avp) or antidiuretic hormone (adh) Reduced ability to excrete free h2o. Including a, b and c- type natriuretic peptides (np) Blunted vasodilatation and natriuresis response to endogenous and exogenous administration of bnp. Bnp is a marker of heart failure severity and prognosis. Is disturbed resulting in endothelial dysfunction and reduced dispensability in heart failure. Elevated endothelin levels with blunted endothelin response to orthostatic (postural) hypotension. Contributes to increased pulmonary vascular resistance. Elevated levels of pro-inflammatory cytokines including tnf-alpha, il1-beta. Contribute to adverse cardiac remodelling, hypertrophy and cardiac cachexia. Often become a feature of acute cardiac decompensation and terminal stages of heart failure. A very common and important clinical syndrome that contributes a major burden of morbidity and mortality. Think of increased demand as well as reduced supply.