IMED3001 Study Guide - Final Guide: Myocardial Infarction, Perfusion, Pulmonary Hypertension

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Document Summary

Heart failure with preserved ejection fraction including diastolic heart failure. Hypertension is the most important/ common form of hfpef. Hypertrophic cardiomyopathy is often inherited as an autosomal dominant condition and can cause death from ventricular arrhythmias. Infiltrative cardiomyopathies (e. g. amyloid) are often multisystem diseases. In diastolic heart failure the pathophysiology differs from that of systolic failure. Reduced compliance/ restriction to filling of the ventricle results in elevated filling pressures. (from lv non-compliance and elevated la pressure) Results in pulmonary oedema, pleural effusions and eventually pulmonary hypertension. Vena cava pressures increase (from rv non-compliance and elevated ra pressure) Results in hepatic congestion, ascites, raised jvp and lower limb oedema. Atrial contraction assists in late diastolic ventricular filling. Atrial fibrillation (with loss of coordinated atrial contraction) is poorly tolerated. (dehydration, acute blood loss, burns, excessive diuretics) (drinking, iv fluids, glucocorticoid [cushing"s] or mineralocorticoid [conn"s] excess, pregnancy)