IMED3001 Study Guide - Midterm Guide: Vasospasm, Coronary Circulation, Tissue Factor

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Document Summary

Retrosternal gripping dull pain, induced by exercise or emotion, relieved by rest or nitro-glycerine. Recurrent prolonged attacks of severe ischaemia caused by episodic focal spasm of a coronary artery. A pre-infarct state due to partial occlusion, may have microinfarct. Fixed atherosclerotic narrowing of the coronary arteries. Fissuring , ulceration, haemorrhage or rupture of atherosclerotic plaques. Tissue factor activates the coagulation pathway. Full thickness necrosis in territory supplied by a single coronary artery. Circumferential necrosis around inner 1/3 to 1/2 of the ventricular wall and may extend beyond the territory supplied by a single coronary artery. Size of vessel(s) obstructed, its site and degree of obstruction. Rapidity of onset of the obstruction. The wave of necrosis spreads from the subendocardial aspect of the ischaemic area and extends outwards. If obstruction is relieved, reperfusion may limit the damage, gives rise to eosinophilic contraction bands, or may result in reperfusion injury probably due to release of free radical.