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PHRM30003 (18)

Study Guides for PHRM30003 at University of Melbourne

Drug Treatment of Disease

PHRM30003 Study Guide - Final Guide: Erlotinib, Ipilimumab, Transforming Growth Factor Beta
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Drug name Drug class Molecular target(s) MechanismFunction ContradictionAENotes Antiallergic (4) Telfast Antihistamines H1 receptor Competitive blockade of histamine binding H1H4 receptors are GPCRs Antiallergic to H1 rece...

Pharmacology
PHRM30003
Christine Wright
PHRM30003 Study Guide - Final Guide: Cytokine, Epistasis, Angiogenesis
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PHRM30003 Exam 2 hr exam part A: 80 mins answer 4 out of 5, write in separate books for each question. Each question is worth 20 marks (20marks x 4) =80 marks in total Advise: spend only around 18 mins, stop and go for ano...

Pharmacology
PHRM30003
Christine Wright
PHRM30003 Study Guide - Final Guide: Secukinumab, Brodalumab, Ustekinumab

Drug name Drug class Molecular target(s) MechanismFunction ContradictionAENotes RA (4) Methotrexate Nonbiological DMARDs TNFalpha Inhibit DNA synthesis by inhibit Cheap (MTX) TNFalpha blocker MTX: Dihydrofolate reductase ...

Pharmacology
PHRM30003
Christine Wright
PHRM30003 Study Guide - Final Guide: Aldosterone, Losartan, Proximal Tubule

Drug name Drug class Molecular target(s) MechanismFunction ContradictionAENotes Hypertension (5) triple therapy Propranolol Nonselective Beta 1 2 AR Decrease HR via SA node Lipidphilic Alprenolol Beta AR antagonist Decr...

Pharmacology
PHRM30003
Christine Wright
PHRM30003 Study Guide - Final Guide: Incretin, Upper Respiratory Tract Infection, Diabetes Mellitus Type 2

Drug name Drug class Molecular target(s) MechanismFunction ContradictionAENotes Type II Diabetes (4) Meglitinides Repaglinide Beta islet For relative lack of insulin Oral Sulphonlureas Rapid onset Stimulate insulin secreti...

Pharmacology
PHRM30003
Christine Wright
PHRM30003 Study Guide - Final Guide: Peroxisome Proliferator-Activated Receptor Alpha, Endosome, Lipoprotein

Drug name Drug class Molecular target(s) MechanismFunction ContradictionAENotes DyslipidaemiaHyperlipidaemia (5) Simvastatin Statin HMGCoA reductase Decrease mevalonic acid AE is dosedependent Etc. So decrease cholesterol ...

Pharmacology
PHRM30003
Christine Wright
PHRM30003 Study Guide - Final Guide: Immune Checkpoint, T790M, Osimertinib

Drug name Drug class Molecular target(s) MechanismFunction ContradictionAENotes Lung Cancer (3) IDO Local immunosuppressant Increase efficacy of immune checkpoint TGF-beta Ipilimumab Immune checkpoint CTLA4 inhibitor Nivol...

Pharmacology
PHRM30003
Christine Wright
PHRM30003 Study Guide - Final Guide: Rituximab, Mast Cell, Melanoma

Drug name Drug class Molecular target(s) MechanismFunction ContradictionAENotes Immunosuppressants (4) used in combination to reduce AE Cyclosporin Calcineurin inhibitor Cyclophilin Inhibit calcineurin inside T cell Discov...

Pharmacology
PHRM30003
Christine Wright
PHRM30003 Study Guide - Final Guide: Vitamin, Liraglutide, Opioid Receptor

Drug name Drug class Molecular target(s) MechanismFunction ContradictionAENotes Obesity (3) need to combine with ow calorie diet and exercise Phentermine Sympathomimetic amine Central Shortterm use Displace NA in presynapt...

Pharmacology
PHRM30003
Christine Wright
PHRM30003 Study Guide - Final Guide: Tachycardia, Angiotensin Ii Receptor Type 1, Bradykinin

Drug name Drug class Molecular target(s) MechanismFunction ContradictionAENotes Heart failure Dysrhythmias (5) Na+ channel blocker Metoprolol Beta AR antagonist Increase SV Carvedilol Meto: cardiac beta1 Car: vascular bet...

Pharmacology
PHRM30003
Christine Wright
PHRM30003 Study Guide - Final Guide: Opioid Overdose, Orthostatic Hypotension, Opioid Receptor

Drug name Drug class Molecular target(s) MechanismFunction ContradictionAENotes Analgesic Morphine U opioid receptor agonist U opioid receptor 1. Peripheral: inhibit Normal inhibitory regulation: NA, GABA, 1. Peripheral 2....

Pharmacology
PHRM30003
Christine Wright
PHRM30003 Study Guide - Final Guide: Asthma, Azithromycin, Omalizumab

Drug name Drug class Molecular target(s) MechanismFunction ContradictionAENotes Asthma Salbutamol SABA Beta2 AR Rapid onset AE: Terbutaline = short acting beta agonist Short duration Beta1 tachycardia Reliever Beta2 tremor...

Pharmacology
PHRM30003
Christine Wright
PHRM30003 Study Guide - Final Guide: Sinoatrial Node, Ivabradine, Isosorbide Dinitrate

Drug name Drug class Molecular target(s) MechanismFunction ContradictionAENotes ISDAngina (4) combination GTN Nitrates Preload (major) Biotransformation to release NO AE: Isosorbide dinitrate Vascular SM in veins Stimulate...

Pharmacology
PHRM30003
Christine Wright
PHRM30003 Study Guide - Final Guide: Hair Loss, Microtubule, Kinase Insert Domain Receptor

Drug name Drug class Molecular target(s) MechanismFunction ContradictionAENotes AntiHER (5) Tratuzumab HER dimerization Dimerised HER HER2: no ligand inhibitorAb Cetuximab AntiEGFR blocking Ab HER1EGFR Antiligand blocking...

Pharmacology
PHRM30003
Christine Wright
PHRM30003 Study Guide - Final Guide: Transrepression, Peptic Ulcer, Cytochrome C Oxidase Subunit Ii

Drug name Drug class Molecular target(s) MechanismFunction ContradictionAENotes Cimetidine H2 selective competitive H2 receptor Competitive antagonist Interacts with many drugs in hepatic antagonist metabolism as interfere...

Pharmacology
PHRM30003
Christine Wright

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