EXSS1029 Study Guide - Final Guide: Myosin, Myosin Head, Modular Design

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Exss1029 muscle mechanics and training: overview of muscle structure. 1. 1 explain the general concept of modular design. Modular design = idea of identical subunits or base units being assemble into larger composite structures. Central feature of modular design allows addition or removal of them units (upscaling or downscaling) of the whole assembly. Modular events occur at a microscopic level which determine a muscles capacity to develop force and change length. Myosin molecule = assembly of several proteins 2 mhc(cid:859)s and 4 mlc(cid:859)s. Mhc larger and heavier than mlc. Specialised to produce active force and movement (single molecule can only produce small amount of force) Large number of myosin molecules = collective output. Stable bonded assembly of 2 mhc + 4 mlc = creates myosin molecule. Mhc is a series of amino acids joined together = known as a polypeptide chain (each chain is unique) Formation of mhc begins with a covalent bond between first and second amino acid.

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