ANHB1102 Study Guide - Final Guide: Balancing Selection, Quantitative Trait Locus, Genetic Counseling

63 views6 pages
TOPIC TWELVE: Genetics
Evolutionary Genetics:
Evolutionary genetics, or microevolution, is genetic change over time. It is the
study of genetic variation within and between organisms. These causes of
genetic variations can be studied through population genetics.
Genetic Variation:
Genetic variation is the catalyst for all evolution, which is a change in allele
frequency over time. The source of all variation is mutation, whether that be
through copy number variation, sequence polymorphisms, chromosome
inversions, or point mutations. On average, humans differ from each other by
0.1%, which implies that each person is a heterozygote at about 1 in 1000
nucleotide pairs. This is referred to as nucleotide diversity, or heterozygosity.
Allele and Genotype Frequencies:
Genotype frequencies are calculated by dividing the number for a particular
genotype by the total population.
However, genotype frequencies can be affected in various ways. The biggest
factor is inbreeding, which is defined as the mating of consanguineous
individuals. Inbreeding has many deleterious biological consequences, which
increase homozygote and decrease heterozygote frequency, usually associated
with recessive conditions.
Allele frequencies are worked out in a similar way to genotype frequencies,
except the number of alleles and the total number of chromosomes are doubled.
find more resources at oneclass.com
find more resources at oneclass.com
Unlock document

This preview shows pages 1-2 of the document.
Unlock all 6 pages and 3 million more documents.

Already have an account? Log in
Allele frequency is the basic measure of the genetic constitution of a population,
and is the basic measure of evolutionary change.
Evolutionary Forces:
Evolution is a change in allele frequency between generations, which causes
genetic variation. The way allele frequencies can be changed are collectively
referred to as evolutionary forces, and include:
1. Mutation, which makes variation
2. Gene flow (migration), which mixes variation
3. Random genetic drift, which deletes variation
4. Natural selection, which selects variation.
Mutation
There are three main principles of mutation:
1. Mutation creates variation
2. Mutation makes only small changes in allele frequencies
3. Overall, mutation is a weak evolutionary force
Some mutations can have a dramatic impact on a population, however mutation
alone cannot change genotype frequencies over a long period of time.
Random Genetic Drift
Random genetic drift can be described as a change in allele frequency due to
chance. Random genetic drift reduces variation, with one allele usually being
lost and the other being fixed in a population. The direction of random genetic
drift is unpredictable as it is mainly due to chance. While it affects all
populations, it has the greatest effect on small, isolated populations, reducing the
genetic variation within their population and increasing the genetic variation
with neighboring populations.
find more resources at oneclass.com
find more resources at oneclass.com
Unlock document

This preview shows pages 1-2 of the document.
Unlock all 6 pages and 3 million more documents.

Already have an account? Log in

Document Summary

Evolutionary genetics, or microevolution, is genetic change over time. It is the study of genetic variation within and between organisms. These causes of genetic variations can be studied through population genetics. Genetic variation is the catalyst for all evolution, which is a change in allele frequency over time. The source of all variation is mutation, whether that be through copy number variation, sequence polymorphisms, chromosome inversions, or point mutations. On average, humans differ from each other by. 0. 1%, which implies that each person is a heterozygote at about 1 in 1000 nucleotide pairs. This is referred to as nucleotide diversity, or heterozygosity. Genotype frequencies are calculated by dividing the number for a particular genotype by the total population. However, genotype frequencies can be affected in various ways. The biggest factor is inbreeding, which is defined as the mating of consanguineous individuals. Inbreeding has many deleterious biological consequences, which increase homozygote and decrease heterozygote frequency, usually associated with recessive conditions.

Get access

Grade+20% off
$8 USD/m$10 USD/m
Billed $96 USD annually
Grade+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
40 Verified Answers

Related Documents

Related Questions