IMED1003 Study Guide - Final Guide: Oxaloacetic Acid, Fatty Acid Synthase, Beta Oxidation
IMED1003 Final Revision Notes 4
LECTURE 13 - see full notes for more details
Fatty Acid:!
-Fatty acid = can get lots of ATP (1FA = 130ATP!
-Oxidizes, strips off electrons (e + O2 = H2O) in FA -> gives lots of energy!
-FA is from:!
1.Diet!
2.Liver synthesise them (in embryo, when mothers lactate)!
When Excess Nutrients:!
-Excess acetyl CoA from diet become FA -> TG -> fats!!!
-(stored more than we need -> obesity)!
Regulation of Citrate:!
When cell needs energy: Citrate -> TCA cycle!
When cell don’t need energy: Citrate relocated -> cytoplasm via transport protein!
NOTE:!
FA synthesis: cytoplasm!
FA breakdown: mitochondria!
(when one inhibited, one
activated)!
Document Summary
Lecture 13 - see full notes for more details. Fatty acid = can get lots of atp (1fa = 130atp. Oxidizes, strips o electrons (e + o2 = h2o) in fa -> gives lots of energy. 2. liver synthesise them (in embryo, when mothers lactate) Excess acetyl coa from diet become fa -> tg -> fats! (stored more than we need -> obesity) When cell needs energy: citrate -> tca cycle. When cell don"t need energy: citrate relocated -> cytoplasm via transport protein. Fa breakdown: mitochondria (when one inhibited, one activated) = at the same time when malate -> pyruvate. = (second source of nadph, a reducing power needed to make fa, on top of ppp in cytosol) Citrate transporter @ imm moves citrate from mitochondria to cytosol. Citrate then carries acetyl group to add to acetyl coa. Acetyl coa is used for fa synthesis. Oxaloacetate with nadh forms malate with enzyme malate dh.
