IMED2001 Study Guide - Final Guide: Phagocyte, Chemokine, Histamine
30 Jun 2018
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IMED2001: Revision Notes 4
Important Convertase:
-C4b2a convertase = Classical and Lectin!
-C3bBb convertase = Alternative!
Complement Cascade:
1) Early phase !
-Get C3 convertase at the end!
-Cleaving C3 -> C3a + C3b!
-C3b acts as opsonin !
-= enhance phagocytosis !
-= acts as a tag on pathogen!
2) Late phase
-(C5-C9 = MAC)!
-Pore channel by C9!
Staph epidermidis = OPPORTUNISTIC
GP Cocci: examples
1. Alpha haemolytic:!
-Incomplete haemolysis!
-> strep mutans, pneumoniae!
2. Beta haemolytic: !
- Complete haemolysis!
-> LF Group A !
-= strep pyogenes: necrotising fasciitis!
-> LF Group B !
-= strep agalactiae: sepsis and meningitis!
Inflammation: 5 signs of inflammation
-Redness!
-Swelling!
-Heat!
-Pain!
-Loss of function!
Vascular Changes:
-Vasucular changes: !
-Redness!
-Swelling!
