IMED2001 Study Guide - Final Guide: Lectin, Drug Resistance, Chemotaxis
30 Jun 2018
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IMED2001: Revision Notes 9
PRRs and PAMPs:
- bind to detect virus!
Important TLR:
-TLR4 (PRR) binds to LPS (PAMPs) found on GNB!
-TLR5 (PRR) binds to flagellin (PAMPs)!
-TLR4/5 = transmembrane receptors!
-TLR3 (PRR) binds to dsRNA (PAMPs)!
-TLR7 (PRR) binds to ssRNA (PAMPs)!
-TLR3 = endosomal receptor!
Pro-inflammatory cytokines:
-promotes inflammation!
-IL-1beta * !
-IL-12!
-TNF alpha *!
-IL-6 *!
4 stages of extravasation:
-(neutrophils moving from blood flow to site of infection)!
-(these are adhesion molcules/receptors. e.g.. selectin, slex, ICAM, LFA)!
1) Rolling adhesion !
- selectin on endothelial and s-Lex on leukocytes!
2) Tight binding !
- ICAM-1 on endothelial and LFA1 on leukocytes!
3) Diapedesis !
= exact motion as it squeezes through endothelial!
4) Migration !
= CHEMOKINE INVOLVED IS CXCL8!
Complement system:
-Alternative: uses C3bBb convertase!
-Classical/Lectin: uses C4b2a convertase!
Alternative: !
-have spontaneous cleavage of C3 -> C3a + C3b!
Classical: !
-need antibodies for cleavage!
