IMED2002 Study Guide - Final Guide: Colonoscopy, Blood Transfusion, Malabsorption
30 Jun 2018
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IMED2002: Revision Notes 11
Lab Features of IDA:
-Mild thrombocytosis!
-Reduced reticulocyte count!
-BM reduced erythropoiesis!
-BM reduce iron stores!
-elevated platelet count !
-= body compensate for blood loss!
-IDA: always due to blood loss so body makes more platelets !
-reticulocytes are earliest RBC in blood!
-In IDA, body struggling to make RBC because depleted of iron, so the reticulocyte
count is also reduced!
-BM reduction in erythropoiesis and iron stores (ferritin)!
-Stain for iron (blue), and red counterstain!
-Prussian blue dye stain ferritin present in macrophages !
-(don’t get morphology of macrophage but can see how much)!
-left: no blue stain at all: no iron present in this BM = IDA!
Laboratory Measures of Iron Status:!
1. Serum iron!
-but it is highly variable !
-Not useful to assess iron stores!
2. Serum transferrin !
-measures iron transporter!
3. Transferrin saturation!
-% of iron transporter that are occupied by iron!
4. Serum ferritin!
-reflects body iron stores!
-other things to do commonly on blood to look at biochemical measures of iron status!
-Measure how much iron in serum !
-(not useful as highly variable, doesn’t tell us how much iron in entire body, only
circulation)!
-amount of transferrin -> goes to BM to make more RBC !
-(reduction of this = BM won’t receive enough iron because it isn’t delivered)!
-Best method: serum ferritin: how much iron stored in body (ferritin is storage molecule)!
Document Summary
Ida: always due to blood loss so body makes more platelets. In ida, body struggling to make rbc because depleted of iron, so the reticulocyte count is also reduced. Bm reduction in erythropoiesis and iron stores (ferritin) Stain for iron (blue), and red counterstain. Prussian blue dye stain ferritin present in macrophages. (don"t get morphology of macrophage but can see how much) Left: no blue stain at all: no iron present in this bm = ida. Laboratory measures of iron status: serum iron. Not useful to assess iron stores: serum transferrin. % of iron transporter that are occupied by iron: serum ferritin. Other things to do commonly on blood to look at biochemical measures of iron status. (not useful as highly variable, doesn"t tell us how much iron in entire body, only circulation) Amount of transferrin -> goes to bm to make more rbc. (reduction of this = bm won"t receive enough iron because it isn"t delivered)
