BIOL 1F25 Study Guide - Midterm Guide: Prostate Cancer, Tumor Suppressor Gene, Basal Lamina
14 Dec 2017
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Document Summary
Cancer is a disease characterized by uncontrolled cell growth. Normal cells die, cancer cells are immortal. The mutation in the tumor suppressor genes block apoptosis. Cancer cells introduce angiogenesis: development of blood supply to a tissue, in cancer they develop it more than normal. Cancer cells are invasive: they over produce proteinases (enzymes that break down good proteins, they degrade basal lamina, by over-producing plasminogen activator (makes plasma, cancer cells are less adhesive than normal cells because of proteins n-cam and e-cadherin. Human development involves a massive increase of # of cells in body; 1 to 1 trillion. Ten quadrillion cell divisions / mitoses happen in lifetime. Cells stop dividing when they reach their final fate. For the process to work you need a form of control, comes from genes. Cancer happens when there is a failure of normal cell division control and apoptosis: result: uncontrolled, immortal cell division. Cancer is a group of diseases with similar characteristics.
