1a.) What do the vast majority of proteins routed through the secretory pathway have in common?
A. They will be secreted.
B. The are post-translationally targeted to their final destination.
C. They are initially post-translationally inserted into the endoplasmic reticulum (ER) lumen.
D. They are co-translationally inserted into the ER lumen.
1b.) Which of the following accurately describes targeting proteins to the mitochondrial matrix or the nucleus?
A. Both mitochondrial matrix and nuclear proteins are co-translationally targeted to their destinations.
B. Both mitochondrial matrix and nuclear proteins are folded only after they reach their destinations.
C. Proteins targeted to the nucleus are completely folded in the cytoplasm. Proteins targeted to the mitochondrial matrix are unfolded while being inserted into the mitochondria and are refolded within the matrix.
D. Proteins targeted to the mitochondrial matrix are completed folded in the cytoplasm. Proteins targeted to the nucleus are unfolded while being inserted into the nucleus and are refolded within the nucleus.
E. None of these statements are correct.