BIOL 3P50 Study Guide - Final Guide: Heteroduplex, Methionine, Centromere

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Chapter 13: mechanisms of transcription: rna polymerase does not need a primer- uses ribonucleotides, rna transcription is less accurate than dna replication, selectively copies only parts. Initiation- rna polymerase binds with initiation factor (sigma) forming the rna polymerase holoenzyme providing specificity that rna pol only binds at promoter- 70 in. 3 models for abortive seq: transient excursion: polymerase briefly escapes promoter, forms <9 nt transcript, aborts and returns to promoter. Inverted repeats followed by a stretch of a:t bp on dna: rna transcript forms a hairpin structure- base-pairing with itself- disrupting elongation complex. Hairpin only effective when followed by a:u pairings. Rnaase degrades the rna 5"-3" until rna pol is reached and is dislodged: allosteric model: when transcript is complete, rna pol undergoes conformational change resulting is lower processivity and spontaneous termination. Control of mating type: eukaryotic repressors: do not work by binding to sites that overlap the promoter and block. Rna polymerase from binding: inhibit transcription by:

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