HLSC 3P19 Study Guide - Midterm Guide: Enzyme Inhibitor, Enzyme, Fetus

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Pharmacodynamics(2): drug, receptor, drug-receptor interaction, and signal transduction. Oral administration: must pas through gut lumen, epithelium, interstitial fluid, capillary endothelium to get to blood (figure 2-3 p10 brenner) Passive diffusion (fick"s law), down gradient, non selective, non saturable: fick"s law: the rate of absorption is proportional to the dug concentration gradient across the barrier and the surface area available for absorption at that site. Ionized form has high water solubility, can not cross cm, protonated weak base: unionized has high lipid solubility, readily cross cm, protonated weak. 3. acid ratio of the two forms influence the rate of absorption and is also a factor in distribution and elimination. Facilitated diffusion, down, selective, saturable: active transport, against, selective, saturable, requires energy (atp) Predict the relative ease of permeation of a weak acid or base from a knowledge of its pka and ph of the medium: ha (protonated form or uncharged) will prevail in a low ph (acidic).

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