HLSC 3P19 Study Guide - Midterm Guide: Inhibitory Postsynaptic Potential, Excitatory Synapse, Membrane Potential

• School: Brock University
• Department: Health Sciences
• Course: HLSC 3P19
• Professor: Fernandez

Document Summary

Activation of metabotropic neurotransmitter receptors lead to modulation of voltage gated channels. When g-protein interacts with calcium channels they inhibit channel functions. This mechanism inhibition of neurotransmitter release which occurs when pre-synaptic metabotropic receptors are activated. When receptors are post-synaptic, they activate (opening) potassium channels which results in a slow post-synaptic inhibition. Metabotropic receptors can have influence on voltage-gated channels less directly by the generation of diffusible second messengers: b-adrenoceptors generate camp via activation of adenylciclase. Effect of metabotropic receptor activation can last tens of seconds to minutes. Metabotropic receptors predominate in the diffuse neuronal system in the cns. Neurons communicate in cns through chemical synapses. Calcium flows into terminal increase in intra-terminal calcium concentration promotes fusion of synaptic vesicles with presynaptic membrane. Neurotransmitter in vesicles released into synaptic cleft diffuses to the receptors on post- synaptic membrane. Neurotransmitter binds to its receptor opens channels brief change in membrane permeability to ions of post-synaptic cell.