HLSC 2P09 Study Guide - Quiz Guide: Neuropeptide Y, Tetraethylammonium, Muscle Tone

• School: Brock University
• Department: Health Sciences
• Course: HLSC 2P09
• Professor: Evangelia Tsiani

Document Summary

Lecture #5: signal transduction, process by which information coming from the extracellular environment is conveyed to the interior of the cell. Information contained in signaling molecules is passed to specific effector molecules within the cell: ligand binds to ligand receptors, only cells that express the specific receptors for a specific ligand will respond to the. Initiation of a cascade of reactions in the cell ligand. Membrane-bound receptors: 7 tm (cid:862)serpe(cid:374)ti(cid:374)e(cid:863) / i(cid:374)tera(cid:272)t (cid:449)ith g proteins, single tm / intrinsic kinase activity (tyrosine, serine, threonine, single tm / interact with tyrosine kinase, cytosolic-nuclear receptors-bound. Receptors containing tyrosine kinase: single tm receptors. Receptors associated with tyrosine kinase: tm receptors, growth hormone. Second messenger hypothesis: hormone, receptor (pm, second messenger, response. Second receptors: 3(cid:859)-5(cid:859) amp (cid:894)(cid:272)amp(cid:895, diacyglycerol (dag, ca++ Important in many signal transduction pathways: net levels of phosphorylation determined by the activity of both, kinases, phosphatases. Kinases: add phosphate group to ser/thr or tyr residues, serine/threonine kinases, tyrosine kinases.