NEUR 3200- Midterm Exam Guide - Comprehensive Notes for the exam ( 41 pages long!)
11 Oct 2017
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Nt get degraded or taken away: be familiar with differences between synthesis and storage of small-molecule vs. peptide. Synthesis of small happens locally within the presynaptic terminals and are packaged in small neurotransmitters clear core vesicles. Peptides are synthesized in the cell body, a long way from where they are released, and peptide filled vesicles transport them to the site of secretion via fast axonal transport. They are packaged in large dense-core vesicles: understand the functions within the synapse of the proteins synapsin, snares, synaptotagmin and clathrin, synapsin anchors vesicles containing nt to actin filaments away from the presynaptic membrane. Synapsin is then phosphorilated by ca/calmodulin-dependent protein kinase type ii (camkii) and dissociated from the vesicle. Once the vesicle is released it moves to dock with the presynaptic membrane: snares= vesicle docking, priming and fusion involves proteins both on the vesicle, and on the presynaptic membrane. Invagination of plasma membrane: understand the basic difference between ionotropic receptors and metabotropic receptors.
