BIOL 366 Study Guide - Final Guide: Karl Ernst Von Baer, Histone H3, Maternal Effect

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Lecture 1: dev bio: study of initiation and construction of organisms, spatial and temporal regulation of gene expression. Temporal regulation: gene is expressed at specific time. Ingression site: change of location of cells during gastrulation: cell types, epithelial cells: tightly connected into sheets or tubes, mesenchymal cells: not connected, operate independently from each other, epithelial to mesenchymal transition. Induced pluripotent stem cells made by expressing 4 different transcription factors (oct3/4, c-myc, Translational regulation: mrna stability, longer half-life = more stable, example: protein prolactin increases half-life of casein mrna (during lactation, mrna accessibility, example: maternal mrna derepression by poly a tail extension, maternal mrna must be expressed at fertilization. Post translational regulation: protein modification, ligand binding, protein stability, gal4-uas system, gal4 is a transcription factor from yeast (protein, unique to yeast, acts as a switch, activates gene downstream. Induction: interaction between 2 cell types that change its fate: produces signal that is detected, competence: ability to respond to signal.

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