BIOL 467 Study Guide - Final Guide: Competitive Inhibition, Sic1, Primase
Document Summary
Somatic cell any cell that is not a sex cell (germ) Rho/rac/ran molecular switch. enzymes that hydrolyze gtp. But their intrinsic activity is low, and needs to be facilitated via a gap. Mitogen - a chemical substance that encourages a cell to commence cell division, triggering mitosis. Ink 4 inhibits cdk4/6 by blocking atp binding: p27 (kip) inhibits e-cdk but promotes d-cdk p21 is a potent cyclin-dependent kinase inhibitor (cki). The p21 (cip1/waf1) protein binds to and inhibits the activity of cyclin-cdk2, -cdk1, and -cdk4/6 complexes, and thus functions as a regulator of cell cycle progression at g1 and s phase. It is a kinase determining the timepoint of entry into mitosis, thus influencing the size of the daughter cells. Loss of wee1 function will produce smaller than normal daughter cell, because cell division occurs prematurely. Wee1 inhibits cdk1 by phosphorylating it on two different sites, tyr15 and thr14.
