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BIOC 3300 Study Guide - Midterm Guide: Hmg-Coa Reductase, Sterol Regulatory Element-Binding Protein, Sterol


Department
Biochem & Molecular Biology
Course Code
BIOC 3300
Professor
Mc Leod Roger
Study Guide
Midterm

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8. SCAP SREBP cleavage-activating protein
9. SREBP
activation
10. SREBP
activation
Sterol regulatory element-binding proteins
(SREBPs) are embedded in the ER when first
synthesized, in a complex with the protein SREBP
cleavage-activating protein (SCAP). When bound
to SCAP, SREBPs are inactive. When sterol levels
decline, the complex migrates to the Golgi
complex, and SREBP is cleaved by two different
proteases in succession. The liberated amino-
terminal domain of SREBP migrates to the
nucleus, where it activates transcription of sterol-
regulated genes.
11. FH
1. Regulation
in
cholesterol
synthesis
2. Regulation
of
cholesterol
synthesis
In mammals, cholesterol production is regulated
by intracellular cholesterol concentration and by
the hormones glucagon and insulin.
The rate-limiting step in the pathway to
cholesterol (and a major site of regulation) is the
conversion of HMGCoA to mevalonate, the
reaction catalyzed by HMG-CoA reductase.
3. ACAT acyl-CoA-cholesterol acyl transferase
4. ACAT
reaction
5. acyl-CoA-
cholesterol
acyl
transferase
catalyzes the transfer of a fatty acid from
coenzyme A to the hydroxyl group of cholesterol,
converting the cholesterol to a more
hydrophobic form. Cholesteryl esters are
transported in secreted lipoprotein particles to
other tissues that use cholesterol, or they are
stored in the liver.
6. HMGCoA
reductase
7. SREBP Sterol regulatory element-binding proteins
Enzymes in Lecture 11-19
Study online at quizlet.com/_22psj9
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