BIOC 3400 Final: BIOC3400 All Lecture Notes
8 Mar 2017
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Two midterms worth 15% each: october 5th and november 4th. Section 1 (liu): focuses on dna replication. Remember diff between acid (phosphate group) and base (the double ring part) For the base group (r) the net charge is +1 when protonated and 0 when deprotonated. When you study nucleic acids, you need to deal with the net charge of the building blocks. Net charge is often used as a tool. In terms of replication you will look at the interaction between the 2 dna strands. Intramolecular interactions are affecting greatly by the net charge of the molecules. Remember when phosphoryl group is deprotonated, net charge is -1, but base group is 0. Nucleoside analogs: antiviral drugs and chemotherapy agents to treat cancer. They are similar enough to nucleosides to be incorporated into growing dna strands. They act as chain terminators and stop viral dna polymerases or reverse transcriptases. Examples: deoxyadenosine, didanosine (ddi, anti-hiv), deoxycytidine, cytarabine, lamivudine.
