MICI 2100 Final: MICI2100 Part 3

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Document Summary

Non-enveloped progeny viruses escape the cell via apoptosis. Enveloped progeny viruses escape the cell in the course of acquiring their lipid envelope in one of two ways: budding into an internal membrane then exocytosis, budding directly from plasma membrane. Many viruses precisely trigger the timing of apoptosis to coincide with their virus assembly completion. If cell triggers apoptosis before the virus is ready, it ca(cid:374)(cid:859)t (cid:373)ake protei(cid:374)s. A delay in apoptosis might allow the cell to detect the virus. Capsids are enveloped inside the cell and use the normal protein secretory pathway for egress. Two possible ways for this to happen (not sure which is correct!) Virus capsid in nucleus, buds into nuclear envelope to pick up membrane, then uses natural. Virus capsid in nucleus, buds into nuclear envelope, de-envelopes coming into cytoplasm, buds into golgi to pick up membrane, then exocytosis.