PHIL 1000X Study Guide - Final Guide: Oncotic Pressure, Renal Corpuscle, Basal Lamina
11 May 2018
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BLOCK YB
MODULE Y5 - RENAL PHYSIOLOGY
UNIT 2
Urine Formation
Unit Objectives
When you have finished this unit, you should be able to:
1. Describe the three filtration barriers and explain how they control what is filtered from the
blood into Bowman's capsule.
a. Capillary endothelium is the FIRST FILTRATION BARRIER
i. Glomerular capillaries are FENESTRATED CAPILLARIES
1. Large pores allow most plasma components to filture through
endothelium but not RBC
b. Basal lamina is SECOND barrier
i. Layer of EC matrix between capillary endothelium and epithelial lining of
Bowman’s capsule
1. Acts like a coarse sieve - excludes most plasma proteins from the
fluid that filters through
c. Epithelium of the Bowman’s Capsule
i. Consists of podocytes
1. Leaves narrow filtration slits - filters out proteins missed by the
previous 2 barriers
2. Describe the main forces that are involved in glomerular filtration, and calculate net
filtration pressure.
a. 3 pressures drive filtration in renal corpuscle
i. Hydrostatic, colloid osmotic, and capsule fluid
ii. Hydrostatic pressure is opposed by colloid osmotic pressure & capsule
fluid
