MIMM 465 Final: MIMM 465 Final Study Guide.docx
14 May 2012
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It has been isolated in 1983 by barry marshall and j. robin warren (australian): in 1984 they identified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Originally, the organism was named campylobacter pylori because of its structural similarity to other campylobacter species, such as c. jejuni (curved shaped). In 1989 it was finally named helicobacter pylori based on genetic evidences (16s rna). This has changed completely the way that gastritis and gastric ulcers are treated (use of antibiotics): two antibiotics and a protein pump inhibitor, originally, they would have used surgery as a therapy. The scientists won the nobel prize in physiology or medicine in 2005. Motile (4-7 flagella at one pole: flagella as well as curved shape are very important for infection. Microaerophilic (oxygen is required, but at levels that are lower than the level in the atmosphere) They care considered to be extracellular pathogens.
